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Pentobarbital (US English) or pentobarbitone (UK English), brand name Nembutal, is a short-acting barbiturate. Pentobarbital can occur as both a free acid and as salts of elements such as sodium and calcium.

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What is Nembutal (Pentobarbital)?

Pentobarbital (US English) or pentobarbitone (UK English), brand name Nembutal, is a short-acting barbiturate. Pentobarbital can occur as both a free acid and as salts of elements such as sodium and calcium. The free acid is only slightly soluble in water and ethanol.

Nembutal (Sodium), Pentobarbital (Sodium) Applications

Medical use

Typical applications for pentobarbital are sedative, hypnotic for short term, preanesthetic and control of convulsions in emergencies.
It is also used as a veterinary anesthetic agent.
Pentobarbital also has an application in reducing intracranial pressure in Reye’s syndrome, traumatic brain injury and induction of coma in cerebral ischemia patients.

Euthanasia

Pentobarbital can induce death when used in high doses. It is used for euthanasia for humans as well as nonhumans. It is also used by itself, or in combination with complementary agents such as phenytoin, in commercial animal euthanasia injectable solutions.

Execution

Pentobarbital has been used or considered as a substitute for other drugs traditionally used for capital punishment in the United States when they are in short supply.

Texas began using pentobarbital for executing death-row inmates by lethal injection on July 18, 2012. The use of pentobarbital has been considered by several states, including Ohio, Arizona, Idaho, and Washington; those states made the decision to switch following shortages of pancuronium bromide, a muscle paralytic previously used as one component in a three-drug cocktail.

In October 2013, Missouri changed its protocols to allow for a compounded pentobarbital to be used in a lethal dose for executions and it was first used in November 2013.

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